Ngemuva kokulimala okukhulu noma okungapheli kwesithiyo se-epidermermal, indlela yokulungisa ezenzakalelayo yesikhumba izosheshisa ukukhiqizwa kwama-keratinocytes, futhi balamule ukukhiqizwa nokukhishwa kwe-cyperkeratosis kanye nokuvuvukala okuncane kwesikhumba. Lokhu futhi kujwayelekile kwezimpawu zesikhumba ezomile.
Ukuvuvukala kwendawo nakho kungandisa ukoma kwesikhumba, eqinisweni, ukuwohloka kwesithiyo se-epidermal kukhuthaza ukuhlanganiswa nokukhululwa kochungechunge lwama-cytokines okuvuvukala, anjenge-z-1he tnf, ikakhulukazi ama-neutrophils, abhujisiwe. Ngemuva kokukhangwa esizeni elomile, ngemuva kokufika lapho uya khona, ama-neutrophils angusizo e-Elastase, uCathepsin G, protagenese 3, kanye ne-collagenase ezithweni ezizungezile, kanye nefomu futhi acebise ama-protease eKeratinocytes. Imiphumela engaba khona yomsebenzi we-protese owengeziwe: 1. Ukulimala kweseli; 2. Ukukhishwa kwama-cytokines avuvukala; I-3. Ukuwohloka ngaphambi kwesikhathi kwe-cell-to-cell oxhumana nabo abakhuthaza ama-mitosis weseli. Umsebenzi we-protelytic enzyme esikhunjeni esomile, esingathinta nezinzwa zemizwa ku-epidermis, zihlotshaniswa nePuritus nobuhlungu. Ukusetshenziswa kwe-Topical of Tranexamic acid kanye ne-α1-antitrypsin (i-protease invibitor) ku-Xerosis kuyasebenza, kuphakamisa ukuthi i-xeroderma ihlotshaniswa nomsebenzi we-exymelytic we-enzyme.
I-epidermis eyomile isho ukuthiIsithiyo sesikhumba siyaphazamiseka, ama-lipid alahlekile, amaprotheni ancishisiwe, futhi kukhishwe izinto zokuvuvukala zasendaweni.Ukoma kwesikhumba okubangelwa ukulimala kwesithiyoIhlukile ku-DRYBENS okubangelwa ukuncishiswa kwe-sebum secreion, futhi umphumela we-leaunce alula ye-LIPID uvame ukwehluleka ukufeza okulindelwe. Izimonyo ezithuthukisiwe zenzelwe ukulimala kwesithiyo akufanele nje zingezele izici zokuthambisa i-stratum Corneum, njengama-cernamides, izimo zemvelo zokuvuvukala, nokunye, kubhekwe ukwahlukanisa okungaphelele kwama-keratinocytes. Isithiyo sokomiswa kwesithiyo kuvame ukuhambisana ne-Pruritus, futhi ukungezwa kwama-antipruritic kufanele kubhekwe.
Isikhathi sePosi: Jun-10-2022
