Ngemuva kokulimala okukhulu noma okungapheli kusithiyo se-epidermal, indlela yokulungisa ezenzakalelayo yesikhumba izosheshisa ukukhiqizwa kwama-keratinocyte, ifinyeze isikhathi sokushintshwa kwamangqamuzana e-epidermal, futhi ilamule ukukhiqizwa nokukhululwa kwama-cytokines, okuholela ku-hyperkeratosis nokuvuvukala okuncane kwesikhumba. . Lokhu kubuye kube yizimpawu zesikhumba esomile.
Ukuvuvukala kwendawo kungase futhi kwandise ukomisa kwesikhumba, empeleni, ukuwohloka kwesithiyo se-epidermal kukhuthaza ukuhlanganiswa nokukhululwa kochungechunge lwama-cytokines ane-pro-inflammatory, njenge-IL-1he TNF, ukuze amangqamuzana omzimba we-phagocytic, ikakhulukazi ama-neutrophils, abhujiswe. Ngemva kokukhangwa endaweni eyomile, ngemva kokufinyelela lapho uya khona, ama-neutrophils akhiqiza i-leukocyte elastase, i-cathepsin G, i-protease 3, ne-collagenase ezicutshini ezizungezile, futhi yakheka futhi inothisa i-protease kuma-keratinocytes. Imiphumela engaba khona yokusebenza ngokweqile kwe-protease: 1. Ukulimala kweseli; 2. Ukukhululwa kwama-cytokines abangela ukuvuvukala; 3. Ukonakala ngaphambi kwesikhathi kokuthintana kweseli kuya kumaseli okuthuthukisa i-cell mitosis. Umsebenzi we-proteolytic enzyme esikhumbeni esomile, okungase futhi kuthinte izinzwa zezinzwa ku-epidermis, kuhlotshaniswa ne-pruritus nobuhlungu. Ukusetshenziswa kwezihloko ze-tranexamic acid ne-α1-antitrypsin (i-protease inhibitor) ku-xerosis kuphumelela, okuphakamisa ukuthi i-xeroderma ihlotshaniswa nomsebenzi we-proteolytic enzyme.
I-epidermis eyomile isho ukuthiumgoqo wesikhumba uphazamisekile, ama-lipids alahlekile, amaprotheni ayancipha, futhi izici zokuvuvukala zendawo zikhishwa.Ukoma kwesikhumba okubangelwa ukulimala kwesithiyoihlukile ekomeni okubangelwa ukuncishiswa kwe-sebum, futhi umphumela we-lipid supplementation elula ngokuvamile uhluleka ukuhlangabezana nokulindelwe. Izimonyo ezithambisayo ezenzelwe ukulimala kwesithiyo akufanele nje zengeze izinto ezimanzisa i-stratum corneum, njenge-ceramides, izinto zemvelo ezithambisayo, njll., kodwa futhi zicabangele imiphumela ye-antioxidant, anti-inflammatory, kanye ne-anti-cell division, ngaleyo ndlela kuncishiswe ukuhlukaniswa okungaphelele. ama-keratinocyte. Ukomisa kwesikhumba okuvinjelwe kuvame ukuhambisana ne-pruritus, futhi ukufakwa kwe-antipruritic actives kufanele kucatshangelwe.
Isikhathi sokuthumela: Jun-10-2022
