Ngemva kokulimala okukhulu noma okungapheli kwesithiyo se-epidermal, indlela yokulungisa isikhumba ngokuzenzakalelayo izosheshisa ukukhiqizwa kwama-keratinocyte, ifinyeze isikhathi sokufakwa kwamaseli e-epidermal, futhi iqondise ukukhiqizwa nokukhululwa kwama-cytokine, okuholela ku-hyperkeratosis kanye nokuvuvukala okuncane kwesikhumba. Lokhu futhi kuyinto evamile yezimpawu zesikhumba esomile.
Ukuvuvukala kwendawo nakho kungandisa ukoma kwesikhumba, empeleni, ukuwohloka kwesithintelo se-epidermal kukhuthaza ukwakheka nokukhululwa kochungechunge lwama-cytokine abangela ukuvuvukala, njenge-IL-1he TNF, ukuze amaseli omzimba e-phagocytic, ikakhulukazi ama-neutrophils, abhujiswe. Ngemva kokukhangwa indawo eyomile, ngemva kokufika lapho uya khona, ama-neutrophils akhipha i-leukocyte elastase, i-cathepsin G, i-protease 3, kanye ne-collagenase ezicutshini ezizungezile, futhi akhe futhi acebise i-protease kuma-keratinocytes. Imiphumela engaba khona yomsebenzi owedlulele we-protease: 1. Ukulimala kweseli; 2. Ukukhishwa kwama-cytokines abangela ukuvuvukala; 3. Ukuwohloka kwangaphambi kwesikhathi kokuxhumana kweseli kuya kweseli okukhuthaza i-cell mitosis. Umsebenzi we-enzyme ye-proteolytic esikhumbeni esomile, ongathinta nemizwa yokuzwa ku-epidermis, uhlotshaniswa nokuqubuka kanye nobuhlungu. Ukusetshenziswa kwe-tranexamic acid kanye ne-α1-antitrypsin (i-protease inhibitor) ku-xerosis kuyasebenza, okuphakamisa ukuthi i-xeroderma ihlotshaniswa nomsebenzi we-enzyme ye-proteolytic.
Isikhumba esomile sisho ukuthiisivikelo sesikhumba siyaphazamiseka, amafutha ayalahleka, amaprotheni ayancishiswa, futhi kukhishwa izici zokuvuvukala zendawo.Ukoma kwesikhumba okubangelwa umonakalo ovimbelayokuhlukile ekomeni okubangelwa ukuncipha kokukhiqizwa kwe-sebum, futhi umphumela wokwengezwa kwamafutha okulula uvame ukwehluleka ukufeza okulindelwe. Izimonyo zokuthambisa eziklanyelwe umonakalo wokuvimbela akufanele nje zengeze izici zokuthambisa ze-stratum corneum, njenge-ceramide, izici zokuthambisa zemvelo, njll., kodwa futhi zicabangele imiphumela yokuhlukaniswa kwe-antioxidant, anti-inflammatory, kanye ne-anti-cell, ngaleyo ndlela kuncishiswe ukuhlukaniswa okungaphelele kwama-keratinocytes. Ukoma kwesikhumba okuvimbela kuvame ukuhambisana nokuklwebheka, futhi kufanele kucatshangelwe ukwengezwa kwezinto ezithambisayo zokuvimbela ukuklwebheka.
Isikhathi sokuthunyelwe: Juni-10-2022
