Izinguquko ze-epidermal structural kanye ne-biochemical ekugugeni kwesikhumba

I-metabolism ye-epidermis iwukuthi ama-basal keratinocyte aya phezulu kancane kancane ngokuhlukaniswa kwamaseli, futhi agcine efa ukuze akhe i-stratum corneum engeyona i-nucleated, bese ewa. Ngokuvamile kukholelwa ukuthi ngokukhula kweminyaka, ungqimba lwe-basal kanye nongqimba lwe-spinous luyaphazamiseka, ukuhlangana kwe-epidermis ne-dermis kuba flat, futhi ubukhulu be-epidermis buyancipha. Njengomgoqo ongaphandle womzimba womuntu, i-epidermis ithintana ngqo nemvelo yangaphandle futhi ithinteka kalula yizici ezihlukahlukene zangaphandle. Ukuguga kwe-epidermal kukhombisa kalula ithonya lobudala nezici zangaphandle ekugugeni komuntu.

Ku-epidermis yesikhumba esiguga, ukuhlukahluka kosayizi, i-morphology kanye nezindawo zokubola zamaseli e-basal layer ziyakhula, ukuhlangana kwe-epidermis ne-dermis kancane kancane kuba flat, uzipho lwe-epidermal luba luncane, futhi ubukhulu be-epidermis buyancipha. Ugqinsi lwe-epidermal lwehla cishe ngo-6.4% ngeshumi leminyaka, futhi lwehla ngokushesha nakakhulu kwabesifazane. Ukuqina kwe-epidermal kuncipha ngokuya ngeminyaka. Lolu shintsho lugqama kakhulu ezindaweni ezisobala, okuhlanganisa indawo engaphezulu yobuso, intamo, izandla, nezingalo. Ama-Keratinocyte ashintsha ukwakheka njengoba isikhumba siguga, siba mfushane futhi sikhuluphele, kuyilapho ama-keratinocyte eba mkhulu ngenxa yoshintsho olufushane lwe-epidermal, isikhathi sokuvuselela i-epidermis yokuguga siyakhula, umsebenzi okhulayo wamangqamuzana e-epidermal uyancipha, futhi i-epidermis iba mncane. mncane, okwenza isikhumba silahlekelwe ukunwebeka nokushwabana.

Ngenxa yalezi zinguquko ze-morphological, i-epidermis-dermis junction ayiqinile futhi isengozini yokulimala kwamandla angaphandle. Inani lama-melanocyte liyehla kancane kancane ngemva kweminyaka yobudala engama-30, amandla okukhula ayancipha, futhi umsebenzi we-enzymatic wama-melanocyte wehla ngesilinganiso sika-8% -20% ngeshumi leminyaka. Nakuba isikhumba kungelula ukuba sibe mnyama, ama-melanocyte athambekele ekwandeni kwendawo ukuze akhe amabala ombala, ikakhulukazi ezindaweni ezichayeke elangeni. Amaseli eLangerhans nawo ayancishiswa, okwenza umsebenzi wokuzivikela esikhumbeni wehle futhi ungenwe kalula yizifo ezithathelwanayo.

I-skin anlayzerumshini ungasetshenziswa ukuthola imibimbi yesikhumba sobuso, ukuthungwa, ukulahleka kwe-collagen, kanye ne-contour yobuso ukusiza ukubona ukuguga kwesikhumba sobuso.