Izinguquko zesakhiwo kanye nezamakhemikhali esikhumbeni ekugugeni kwesikhumba

I-metabolism ye-epidermis iwukuthi ama-keratinocyte aqala ukukhuphuka kancane kancane ngokuhlukaniswa kwamaseli, bese ekugcineni efa ukuze akhe i-stratum corneum engeyona i-nucleated, bese ewa. Ngokuvamile kukholelwa ukuthi ngokwanda kokuguga, ungqimba oluyisisekelo kanye nongqimba oluyi-spinous kuyaphazamiseka, ukuhlangana kwe-epidermis kanye ne-dermis kuba yisicaba, futhi ukujiya kwe-epidermis kwehla. Njengesithiyo esingaphandle somzimba womuntu, i-epidermis ixhumana ngqo nendawo yangaphandle futhi ithinteka kalula yizici ezahlukahlukene zangaphandle. Ukuguga kwe-epidermal kubonisa kalula ithonya lokuguga kanye nezici zangaphandle ekugugeni kwabantu.

Ku-epidermis yesikhumba esigugayo, ukuguquguquka kosayizi, isimo kanye nezakhiwo zokufaka umbala zamaseli e-basal layer kuyanda, ukuhlangana kwe-epidermis kanye ne-dermis kancane kancane kuba yisicaba, uzipho lwe-epidermal luyajula, kanti ugqinsi lwe-epidermal luyancipha. Ugqinsi lwe-epidermal luncipha cishe ngo-6.4% ngeshumi leminyaka, futhi luncipha ngokushesha nakakhulu kwabesifazane. Ugqinsi lwe-epidermal luncipha ngokuguga. Lolu shintsho lubonakala kakhulu ezindaweni eziveziwe, okuhlanganisa ubuso obunwebekayo bobuso, intamo, izandla, kanye nezingalo. Ama-Keratinocyte ashintsha isimo njengoba isikhumba siguga, siba sifushane futhi sikhuluphele, kuyilapho ama-keratinocyte eba makhulu ngenxa yokuguquka kwe-epidermal okufushane, isikhathi sokuvuselelwa kwe-epidermal esigugayo siyanda, umsebenzi wokwanda kwamaseli e-epidermal uyancipha, futhi i-epidermis iba mncane., okubangela ukuba isikhumba silahlekelwe ukuqina kanye nokushwabana.

Ngenxa yalezi zinguquko zesimo somzimba, i-epidermis-dermis junction ayiqinile futhi ayisengozini yokulimala kwamandla angaphandle. Inani lama-melanocyte liyancipha kancane kancane ngemva kweminyaka engama-30, amandla okukhula ayancipha, futhi umsebenzi we-enzymatic wama-melanocyte uyancipha ngesilinganiso esingu-8%-20% ngeshumi leminyaka. Nakuba isikhumba singelula ukusishintsha sibe nsundu, ama-melanocyte athambekele ekukhuleni kwendawo ukuze akhe amabala ombala, ikakhulukazi ezindaweni ezivezwe yilanga. Amaseli e-Langerhans nawo ayancishiswa, okwenza ukusebenza komzimba wesikhumba kwehle futhi kube lula ukuthola izifo ezithathelwanayo.

I-anlayzer yesikhumbaUmshini ungasetshenziswa ukuthola imibimbi yesikhumba sobuso, ukuthungwa, ukulahleka kwe-collagen, kanye nokwakheka kobuso ukusiza ukuthola ukuguga kwesikhumba sobuso.