Indlela entsha yokwelashwa kwe-rosacea kusetshenziswa ubuchwepheshe obuphezulu be-pulse: In vivo kanye nezifundo zomtholampilo

Ingemuva:I-Rosacea yisifo sesikhumba esivuthayo esingapheli esithinta ubuso, futhi umphumela wokwelapha wamanje awugculisi.Ngokusekelwe ku-photomodulation ye-optimal pulse technology (OPT), sithuthukise imodi yokwelapha inoveli, okungukuthi, i-OPT ethuthukisiwe enamandla aphansi, ama-pulses amathathu, nobubanzi be-pulse ende (AOPT-LTL).

Izinjongo:Sasihlose ukuhlola ukuba nokwenzeka kanye nezindlela eziyisisekelo zamamolekyuli zokwelashwa kwe-AOPT-LTL kumodeli yegundane elifana ne-rosacea.Ngaphezu kwalokho, sihlole ukuphepha nokusebenza ngempumelelo ezigulini ezine-erythematotelangiectatic rosacea (ETR).

Izimpahla nezindlela:Ukuhlaziywa kwe-morphological, histological, kanye ne-immunohistochemical kwasetshenziswa ukuze kuphenywe ukusebenza kahle nezindlela zokwelashwa kwe-AOPT-LTL kumodeli yegundane efana ne-LL-37-induced rosacea.Ngaphezu kwalokho, iziguli ze-23 ezine-ETR zifakiwe futhi zithole izikhathi zokwelashwa ezihlukene ngezikhathi zamaviki e-2 kuye ngobunzima besimo sabo.Umphumela wokwelapha uhlolwe ngokuqhathanisa izithombe zomtholampilo ekuqaleni, isonto le-1, nezinyanga ezingu-3 ngemva kokwelashwa, kuhlanganiswe nenani elibomvu, i-GFSS, nezikolo ze-CEA.

Imiphumela:Ngemuva kokwelashwa kwe-AOPT-LTL yamagundane, sabona ukuthi i-phenotype efana ne-rosacea, ukungena kwamaseli okuvuvukala, nokungajwayelekile kwemithambo kwathuthukiswa kakhulu, futhi ukuvezwa kwama-molecule ayinhloko we-rosacea kwakuvinjelwe kakhulu.Ocwaningweni lomtholampilo, ukwelashwa kwe-AOPT-LTL kube nemiphumela eyanelisayo yokwelapha ku-erythema kanye nokuguquguquka kweziguli ze-ETR.Azikho izehlakalo ezimbi ezimbi ezabonwa.

Iziphetho:I-AOPT-LTL iyindlela ephephile nesebenzayo yokwelashwa kwe-ETR.