Indlela entsha yokwelapha i-rosacea kusetshenziswa ubuchwepheshe be-pulse obuhle kakhulu: Izifundo ze-In vivo kanye nezokwelapha

Ingemuva:I-Rosacea isifo sesikhumba esingapheli esithinta ubuso, futhi umphumela wamanje wokwelashwa awugculisi. Ngokusekelwe ekuguqulweni kwe-photomodulation kwe-optimal pulse technology (OPT), sakha indlela entsha yokwelapha, okungukuthi, i-OPT ethuthukisiwe enamandla aphansi, ama-pulse amathathu, kanye nobubanzi be-pulse obude (AOPT-LTL).

Izinhloso:Sihlose ukuhlola ukuthi kungenzeka yini kanye nezindlela zama-molecule eziyisisekelo zokwelashwa kwe-AOPT-LTL kumodeli yegundane efana ne-rosacea. Ngaphezu kwalokho, sihlole ukuphepha kanye nokusebenza kahle kweziguli ezine-erythematotelangiectatic rosacea (ETR).

Izimpahla nezindlela:Ukuhlaziywa kwesimo somzimba, i-histological, kanye ne-immunohistochemical kusetshenziswe ukuphenya ukusebenza kahle kanye nezindlela zokwelashwa kwe-AOPT-LTL kumodeli yegundane efana ne-LL-37 ebangelwe yi-rosacea. Ngaphezu kwalokho, iziguli ezingu-23 ezine-ETR zafakwa futhi zathola izikhathi ezahlukene zokwelashwa ngezikhawu zamasonto ama-2 kuye ngokuthi isimo sazo sibucayi kangakanani. Umphumela wokwelashwa wahlolwa ngokuqhathanisa izithombe zemitholampilo ekuqaleni, isonto eli-1, kanye nezinyanga ezi-3 ngemuva kokwelashwa, kuhlanganiswe nenani elibomvu, amaphuzu e-GFSS, kanye ne-CEA.

Imiphumela:Ngemva kokwelashwa kwe-AOPT-LTL kwamagundane, sabona ukuthi i-phenotype efana ne-rosacea, ukungena kwamaseli okuvuvukala, kanye nokukhubazeka kwemithambo yegazi kwancishiswa kakhulu, kanti ukuvezwa kwama-molecule ayinhloko e-rosacea kwavinjelwa kakhulu. Esifundweni somtholampilo, ukwelashwa kwe-AOPT-LTL kube nemiphumela eyanelisayo yokwelapha ku-erythema kanye nokuhlanzwa kweziguli ze-ETR. Azikho izehlakalo ezimbi kakhulu ezibonwe.

Iziphetho:I-AOPT-LTL iyindlela ephephile nephumelelayo yokwelapha i-ETR.