Ihomoni iyehla ngokukhula, okuhlanganisa i-estrogen, i-testosterone, i-dehydroepiandrosterone sulfate, ne-hormone yokukhula. Imiphumela yama-hormone esikhumbeni miningi, okuhlanganisa ukwanda kokuqukethwe kwe-collagen, ukushuba kwesikhumba okukhuphukile, kanye nokukhishwa kwesikhumba okuthuthukisiwe. Phakathi kwazo, ithonya le-estrogen libonakala ngokucacile, kodwa indlela yethonya layo kumaseli ayikaqondwa kahle. Umphumela we-estrogen esikhumbeni ubonakala ikakhulukazi ngama-keratinocyte e-epidermis, ama-fibroblasts nama-melanocytes e-dermis, kanye namangqamuzana ezinwele ze-follicle nezindlala ze-sebaceous. Lapho ikhono labesifazane lokukhiqiza i-estrogen lincipha, inqubo yokuguga kwesikhumba iyashesha. Ukuntuleka kwe-hormone estradiol kunciphisa umsebenzi we-basal layer ye-epidermis futhi kunciphisa ukuhlanganiswa kwe-collagen nemicu yokunwebeka, konke okubalulekile ekugcineni ukunwebeka okuhle kwesikhumba. Ukwehla kwamazinga e-estrogen angemva kokumenopausal akuholeli nje kuphela ekwehleni kokuqukethwe kwe-collagen yesikhumba, kodwa futhi nokusetshenziswa kwe-metabolism yamangqamuzana esikhumba kuthinteka amazinga aphansi e-estrogen angemva kokumenopausal, futhi lezi zinguquko zingahlehliswa ngokushesha ngokusetshenziswa kwezihloko ze-estrogen. Ukuhlola kuye kwaqinisekisa ukuthi i-estrogen ye-topical wesifazane ingakhuphula i-collagen, igcine ukujiya kwesikhumba, futhi igcine umswakama wesikhumba kanye nomsebenzi ovimbelayo we-stratum corneum ngokwandisa i-acidic glycosaminoglycans ne-hyaluronic acid, ukuze isikhumba sigcine ukunwebeka okuhle. Kungabonakala ukuthi ukwehla komsebenzi wesistimu ye-endocrine futhi kungenye yezinto ezibalulekile ezithonya indlela yokuguga kwesikhumba.
Ukuncipha kokukhiqizwa kwe-pituitary, i-adrenal, ne-gonads kunomthelela ekushintsheni kwesici ku-phenotype yomzimba nesikhumba kanye namaphethini okuziphatha ahambisana nokuguga. Amazinga e-serum ye-17β-estradiol, i-dehydroepiandrosterone, i-progesterone, i-hormone yokukhula, kanye ne-hormone yabo ephansi ye-insulin ukukhula factor (IGF) -I yehla ngokukhula. Kodwa-ke, amazinga we-hormone yokukhula kanye ne-IGF-I ku-serum yesilisa ehle kakhulu, futhi ukwehla kwamazinga e-hormone kwezinye izakhamuzi kungase kwenzeke esiteji esidala. Amahomoni angathinta isimo nokusebenza kwesikhumba, ukungakwazi ukungena kwesikhumba, ukuphulukiswa, i-cortical lipogenesis, kanye ne-metabolism yesikhumba. I-Estrogen replacement therapy ingavimbela ukuya esikhathini nokuguga kwesikhumba okungapheli.
——“Skin Epiphysiology” Yinmao Dong, Laiji Ma, Chemical Industry Press
Ngakho-ke, njengoba sikhula, ukunaka kwethu izimo zesikhumba kufanele kukhule kancane kancane. Singasebenzisa uchwepheshe othileimishini yokuhlaziya isikhumbaukubuka nokubikezela isigaba sesikhumba, ukubikezela izinkinga zesikhumba kusenesikhathi, futhi ubhekane nazo ngenkuthalo.
Isikhathi sokuthumela: Jan-05-2023
