Izinto Ezintathu Zokuguga Kwesikhumba

Isici sokuqala ekugugeni kwesikhumba:

Imisebe ye-UV, ukuthwebula izithombe

U-70% wokuguga kwesikhumba usuka ekuthatheni izithombe

Imisebe ye-UV ithinta i-collagen emizimbeni yethu, egcina isikhumba sibukeka sisisha. Uma i-collagen incipha, isikhumba sizoba nokuncipha kokunwebeka, ukuwohloka, ubuthuntu, ithoni yesikhumba engalingani, i-hyperpigmentation, i-pigmentation nezinye izinkinga zesikhumba.

Ububanzi belanga obubanzi buhlukaniswe i-UVA ne-UVB. Imisebe ye-UVB inobude obufushane obungamaza futhi ingashisa kuphela ungqimba olungaphezulu lwesikhumba sethu, ingakwazi ukungena ijule esikhunjeni; Nokho, imisebe ye-UVA inamaza amade amade futhi ingangena ngengilazi futhi ijule esikhumbeni, ekugcineni yenze buthaka i-collagen futhi iholele ekukhuleni kwemibimbi.

Ngamagama alula, i-UVA iholela ekugugeni, i-UVB iholela ekushiseni, futhi ukukhanya kwe-ultraviolet kungalimaza i-DNA yeselula, kunciphise umsebenzi we-fibroblast, futhi ukuhlanganiswa kwe-collagen kuyavinjwa, okuholela ekuguqulweni kweseli, ukuguga, kanye ne-apoptosis. Ngakho, i-UV ikhona yonke indawo, kungakhathaliseki ukuthi libalele noma linamafu, udinga ukwenza umsebenzi omuhle wokuvikela ilanga.

Isici sesibili esibaluleke kakhulu ekugugeni kwesikhumba

Ama-radicals wamahhala we-oxidative

Igama eliyinhloko lama-radicals mahhala lithi 'oksijini'. Siphefumula cishe amaphesenti angama-98 kuya kwangu-99 omoya-mpilo njalo lapho siphefumula; isetshenziselwa ukushisa ukudla esikudlayo futhi ikhiphe ama-molecule amancane ukuze amangqamuzana ethu asebenze, futhi ikhipha amandla amaningi ukwenza imisipha yethu isebenze.

Kodwa mhlawumbe u-1% noma u-2% womoya-mpilo ukhetha indlela ehlukile futhi eyingozi, leli nani elincane lomoya-mpilo, ngokuvamile elibizwa ngokuthi ama-radicals mahhala, ahlasela amangqamuzana ethu. Ngokuhamba kwesikhathi, lo monakalo uyanqwabelana ngokuhamba kwesikhathi.

Okuphawuleka kakhulu yizimpawu zokuguga ezibonakala esikhumbeni. Umzimba wethu unendlela yokuzivikela elungisa umonakalo owenziwe kumangqamuzana ethu ngama-radicals mahhala, kodwa lapho ama-radicals mahhala enqwabelana ngokushesha kunokuba amangqamuzana omzimba akwazi ukuwalungisa, isikhumba siyaguga kancane kancane.

Isithombe esingenhla yizicubu zesikhumba sangempela somzimba wethu, ungabona ngokucacile ukuthi i-epidermis engaphezulu imnyama futhi i-dermis engezansi ikhanya kancane, i-dermis yilapho sikhiqiza khona i-collagen, kanti amaseli akhiqiza i-collagen abizwa ngokuthi ama-fibroblasts, imishini yokwenza i-collagen.

Ama-fibroblasts aphakathi nesithombe ama-fibroblasts, kanti i-spider web ewazungezile yi-collagen. I-Collagen ikhiqizwa ama-fibroblasts, futhi isikhumba esincane siyinethiwekhi ye-collagen enezinhlangothi ezintathu futhi ebunjwe ngokuqinile, enama-fibroblasts adonsa ngamandla ama-collagen fibers ukunikeza isikhumba esincane ukuthungwa okugcwele nokushelelayo.

Futhi isikhumba esidala, ama-fibroblasts kanye nesixhumanisi se-collagen phakathi kokuhlakazeka kwe-fibroblasts eguga ngokuvamile sizokwenqaba ukungena kwe-collagen, ngokuhamba kwesikhathi, isikhumba saqala ukuguga, yilokhu esivame ukukusho ukuguga kwesikhumba, siyixazulula kanjani i-oxidation isikhumba samukelwe?

Ngaphezu kokunaka kakhulu i-sunscreen, singasebenzisa ezinye nge-vitamin A, i-vitamin E, i-ferulic acid, i-resveratrol nezinye izithako zemikhiqizo yokunakekelwa kwesikhumba; ngokuvamile angadla izithelo nemifino enemibala egqamile, njengotamatisi, utamatisi ucebile nge-lycopene.

Ingakwazi ukumunca umoya-mpilo kahle futhi ivimbele ukucindezeleka okwenziwe nge-oxidative, ungadla futhi i-broccoli eyengeziwe, i-broccoli iqukethe ingxenye ebizwa ngokuthi i-mustard oil glycosides, ngemva kokungena kwalesi sithako, izogcinwa esikhumbeni, ukuze amangqamuzana esikhumba akwazi ukuzivikela. , lezi zithelo nemifino kungakhuthaza ukumelana kwamangqamuzana ekugugeni.

Isici sesithathu esibaluleke kakhulu ekugugeni kwesikhumba

I-Skin glycation

I-Glycation, ngokwemibandela yobungcweti, ibizwa ngokuthi i-non-enzymatic glycosylation reaction noma i-Melad reaction. Isimiso siwukuthi ukunciphisa ushukela kubopha amaprotheni ngokungabikho kwama-enzyme; ukunciphisa ushukela kuguqulwa kakhulu ngamaprotheni, futhi ukunciphisa ushukela namaprotheni kudlula isikhathi eside se-oxidation, i-dehydrogenation, kanye nokuhlela kabusha, okuholela ekukhiqizweni kwemikhiqizo yokuphela kwe-glycosylation yesigaba sekwephuzile, noma ama-AGE ngamafuphi.

Ama-AGE ayiqembu lemfucumfucu engenakuhlehliswa, ephuzi ngokunsundu, ehambisanayo engesabi ukubhujiswa kwama-enzyme, futhi ingenye yezimbangela eziyinhloko zokuguga komuntu. Njengoba sikhula, ama-AGE anqwabelana emzimbeni, okuholela ekwandeni kokuqina kwezindonga zangaphakathi zemithambo yegazi, ukungalingani kwe-metabolism yamathambo okuholela ku-osteoporosis, nokubhujiswa kwe-collagen ne-elastin fibers ku-dermis okuholela ekugugeni kwesikhumba. Ukuguga kwesikhumba okubangelwa i-glycation kufinyezwa emushweni owodwa: ushukela ubhubhisa amaprotheni anempilo futhi uguqule izakhiwo zamaprotheni ezincane zibe izakhiwo zamaprotheni ezindala, okuholela ekugugeni nasekulahlekelweni kokunwebeka. i-collagen kanye ne-elastic fibers ku-dermis.