Izici Ezintathu Zokuguga Kwesikhumba

Isici esiyinhloko ekugugeni kwesikhumba:

imisebe ye-UV, ukuthwebula izithombe

Ama-70% okuguga kwesikhumba avela ekusetshenzisweni kwezithombe

Imisebe ye-UV ithinta i-collagen emizimbeni yethu, egcina isikhumba sibukeka sisisha. Uma i-collagen incipha, isikhumba sizoba nokuqina okunciphile, ukugoba, ukufiphala, ithoni yesikhumba engalingani, i-hyperpigmentation, i-pigmentation nezinye izinkinga zesikhumba.

I-spectrum ebanzi yelanga ihlukaniswe nge-UVA kanye ne-UVB. Imisebe ye-UVB inama-wavelength amafushane futhi ingashisa kuphela ungqimba oluphezulu lwesikhumba sethu, ingakwazi ukungena ngokujulile esikhumbeni; noma kunjalo, imisebe ye-UVA inama-wavelength amade futhi ingangena ngengilazi futhi ijule esikhumbeni, ekugcineni inciphise i-collagen futhi iholele ekukhuleni kwemibimbi.

Kalula nje, i-UVA iholela ekugugeni, i-UVB iholela ekushiseni, kanti ukukhanya kwe-ultraviolet kungalimaza i-DNA yamangqamuzana, kunciphise umsebenzi we-fibroblast, futhi ukwakheka kwe-collagen kuvinjiwe, okuholela ekuguqukeni kwamangqamuzana, ekugugeni, kanye ne-apoptosis. Ngakho-ke, i-UV ikhona yonke indawo, kungakhathaliseki ukuthi kunelanga noma kunefu, udinga ukwenza umsebenzi omuhle wokuvikela ilanga.

Isici sesibili esibaluleke kakhulu ekugugeni kwesikhumba

Ama-radical wamahhala a-oxidative

Igama eliyinhloko lama-free radicals lithi 'i-oxygen'. Siphefumula cishe amaphesenti angama-98 kuya kwangu-99 omoya-mpilo njalo uma siphefumula; usetshenziselwa ukushisa ukudla esikudlayo nokukhulula ama-molecule amancane ukuze amangqamuzana ethu asebenze, futhi ukhipha amandla amaningi ukuze imisipha yethu isebenze.

Kodwa mhlawumbe u-1% noma u-2% womoya-mpilo ukhetha indlela ehlukile neyingozi, leli nani elincane lomoya-mpilo, elivame ukubizwa ngokuthi ama-free radicals, ahlasela amangqamuzana ethu. Ngokuhamba kwesikhathi, lo monakalo uyanqwabelana ngokuhamba kwesikhathi.

Okuphawuleka kakhulu izimpawu zokuguga ezibonakala esikhumbeni. Umzimba wethu unendlela yokuzivikela elungisa umonakalo owenziwe kumaseli ethu ngama-free radicals, kodwa lapho ama-free radicals eqoqana ngokushesha kunalokho amaseli omzimba angakulungisa, isikhumba siyaguga kancane kancane.

Isithombe esingenhla yizicubu zesikhumba zangempela zomzimba wethu, ungabona ngokucacile ukuthi i-epidermis ephezulu imnyama kanti i-dermis engezansi ikhanya kancane, i-dermis yilapho sikhiqiza khona i-collagen, kanti amaseli akhiqiza i-collagen abizwa ngokuthi ama-fibroblast, okuyimishini yokwenza i-collagen.

Ama-fibroblast aphakathi nesithombe yi-fibroblast, kanti i-spider web ewazungezile yi-collagen. I-Collagen ikhiqizwa yi-fibroblast, kanti isikhumba esincane siwuhlelo lwe-collagen olunezinhlangothi ezintathu futhi oluhlanganiswe kahle, lapho ama-fibroblast edonsa khona imicu ye-collagen ngamandla ukuze anikeze isikhumba esincane ukuthungwa okugcwele nokubushelelezi.

Futhi isikhumba esidala, ama-fibroblast kanye nokuxhumana kwe-collagen phakathi kokuqhekeka kwama-fibroblast asebekhulile kuvame ukwenqaba ukungena kwe-collagen, ngokuhamba kwesikhathi, isikhumba naso saqala ukuguga, yilokhu esivame ukukusho ukuguga kwesikhumba, siyixazulula kanjani i-oxidation yesikhumba esitholiwe?

Ngaphezu kokunaka kakhulu umuthi wokuvikela isikhumba, singasebenzisa eminye enevithamini A, ivithamini E, i-ferulic acid, i-resveratrol nezinye izithako zemikhiqizo yokunakekelwa kwesikhumba; ngokuvamile singadla nezithelo nemifino enemibala egqamile, njengotamatisi, utamatisi ucebile nge-lycopene.

Ingamunca kahle umoya-mpilo futhi ivimbele ukucindezeleka kwe-oxidative, ungadla futhi i-broccoli eningi, i-broccoli iqukethe ingxenye ebizwa ngokuthi i-mustard oil glycosides, ngemva kokuthatha lesi sithako, izogcinwa esikhumbeni, ukuze amangqamuzana esikhumba akwazi ukuzivikela, lezi zithelo nemifino kungakhuthaza ukumelana kwamangqamuzana nokuguga.

Isici sesithathu esibaluleke kakhulu ekugugeni kwesikhumba

Ukwehliswa kwesikhumba

I-Glycation, ngokwemigomo yobungcweti, ibizwa ngokuthi i-non-enzyme glycosylation reaction noma i-Melad reaction. Isimiso siwukuthi ukunciphisa ushukela kubopha amaprotheni uma kungekho ma-enzyme; ukunciphisa ushukela kuguqulwa kakhulu ngamaprotheni, futhi ukunciphisa ushukela namaprotheni kuthola ukusabela okude kwe-oxidation, dehydrogenation, kanye nokuhlelwa kabusha, okuholela ekukhiqizweni kwemikhiqizo yokugcina ye-glycosylation yesigaba sakamuva, noma ama-AGE ngamafuphi.

Ama-AGE ayiqembu lemfucuza yezinto eziphilayo engaphikiswa, ephuzi-nsundu, ehlobene nayo engesabi ukubhujiswa kwama-enzyme, futhi ingenye yezimbangela eziyinhloko zokuguga kwabantu. Njengoba siguga, ama-AGE aqoqana emzimbeni, okuholela ekwandeni kobulukhuni bezindonga zangaphakathi zemithambo yegazi, ukungalingani ekusebenzeni kwamathambo okuholela ekuwohlokeni kwamathambo, kanye nokubhujiswa kwemicu ye-collagen ne-elastin ku-dermis okuholela ekugugeni kwesikhumba. Ukuguga kwesikhumba okubangelwa yi-glycation kufingqwe ngomusho owodwa: ushukela ubhubhisa amaprotheni anempilo futhi uguqula izakhiwo zamaprotheni amancane zibe izakhiwo zamaprotheni ezindala, okuholela ekugugeni nasekulahlekelweni kokuqina kwe-collagen kanye nemicu ye-elastic ku-dermis.