Izimonyo ezimhlophe futhiIsikhumbaUmshini omubi
I-Melanin Anabolism ihlukaniswe ngezikhathi ezahlukahlukene. Ososayensi bakholelwa ukuthi kungenzeka ukutadisha abenzeli abamhlophe futhi basebenze ngezikhathi ezahlukahlukene ze-metabolic.
(1) Isigaba sokuqala se-melanin synthesis
① Xhumanisa umbhalo kanye / noma glycosylulation ye-tyrosinase; ② Vimbela abalawuli ekwakhekeni kweTyrosinase; ③ Ukulawulwa kokuthunyelwa kwe-post-trapjiswase kwe-tyrosinase.
(2) Isikhathi se-Melanin Synthesis
Njengoba i-enzyme ebalulekile ne-rate-inving enzyme ye-melanin synthesis, ama-tyrosinase inhibitors kukhona ucwaningo oluphambili kanye nokuqondiswa kwentuthuko njengamanje. Njengoba ama-ejenti amhlophe amhlophe anjenge-phenol kanye ne-catechool derivatives afana ne-tyrosine ne-dopa, ama-ejenti amhlophe ahlolwe avame ukuhlukaniswa njengokuncintisana kwe-tyrominase okuncintisanayo.
(3) Isigaba sekwephuzile se-melanin synthesis
①Inhibits melanosome ukudluliswa; izinto ezinomphumela we-serine protease inhibitory umphumela, njenge-rwj-50353, gwema ngokuphelele i-UBV-inconder pigmermal; I-soybean trypsin inhibitor inomphumela osobala osobala kepha awunamthelela ubuthi bamaseli wengulube; INiacinamide, ingavimba ukuhanjiswa kwama-melanocytes phakathi kwama-melanocytes nama-keratinocytes; ② Ukuhlakazeka kwe-melanin kanye ne-metabolism, i-α-hydroxy acid, mahhala i-acid ye-acid ye-redinoic, vusa ukuvuselelwa kweseli kanye nokuqhakambisa ama-keratinocytes asuswayo.
Kuyaqapheleka ukuthi ucwaningo nokusetshenziswa kwezinto ezimhlophe ezisuselwa ku-Melanin Metabolism engenhla azilungele ukuvimbela nokwelashwa kwama-senile plaque. Njengoba indlela yokwakheka kwe-senile plaque ihlobene nokwakheka kwe-lipofuscin, izinto ezisebenzayo ze-antioxidative zivame ukusetshenziswa ukubambezeleka kanye nokubuyisela emuva ama-senile plaques.
Isikhathi Seposi: Jul-29-2022
