Izimonyo ezimhlophe kanyeI-PigmentI-Metabolism
I-Melanin anabolism ihlukaniswe ngezikhathi ezahlukene. Ososayensi bakholelwa ukuthi kuyenzeka ukufunda ama-ejenti amhlophe futhi asebenze izikhathi ezihlukene ze-metabolic.
(1) Isigaba sokuqala se-melanin synthesis
① Ukuphazamisa ukuloba kanye/noma i-glycosylation ye-tyrosinase; ② Vimbela izilawuli ekwakhekeni kwe-tyrosinase; ③ Ukulawulwa kwangemuva kokubhala kwe-tyrosinase.
(2) Isikhathi se-melanin synthesis
Njenge-enzyme eyinhloko kanye ne-enzyme enciphisa izinga le-melanin synthesis, i-tyrosinase inhibitors iyisiqondiso esiyinhloko socwaningo nentuthuko okwamanje. Njengoba iningi lama-ejenti amhlophe afana nokuphuma kwe-phenol ne-catechol kufana nesakhiwo ne-tyrosine ne-dopa, ama-ejenti amhlophe ahlolwayo ngokuvamile ahlukaniswa njengama-inhibitor angaqhudelani noma aqhudelanayo e-tyrosinase.
(3) Isigaba sakamuva se-melanin synthesis
①Ivimbela ukudluliswa kwe-melanosome; izinto ezinomphumela we-serine protease inhibitory, njenge-rwj-50353, zigwema ngokuphelele i-epidermal pigmentation eyenziwe yi-UBV; i-soybean trypsin inhibitor inomphumela osobala wokuba mhlophe kodwa ayinawo umthelela kubuthi bamaseli e-pigment; I-Niacinamide, ingavimbela ukudluliswa kwama-melanocyte phakathi kwama-melanocyte nama-keratinocyte; ② Ukuhlakazeka kwe-melanin kanye ne-metabolism, i-α-hydroxy acid, i-fatty acid yamahhala ne-retinoic acid, ivuselela ukuvuselelwa kwamaseli futhi ikhuthaze ukususwa kwama-keratinocyte e-melaninized.
Kuyaqapheleka ukuthi ucwaningo kanye nokusetshenziswa kwezinto ezimhlophe ezisuselwa kumetabolism engenhla ye-melanin akufanelekile ukuvinjwa nokwelashwa kwama-senile plaque. Njengoba indlela yokwakheka kwe-senile plaque ihlobene nokwakheka kwe-lipofuscin, izinto ezisebenzayo ze-antioxidative zivame ukusetshenziselwa ukubambezeleka nokuhlehlisa izingcezu ze-senile.
Isikhathi sokuthumela: Jul-29-2022
