Izimonyo Zokwenza Umhlophe kanyeI-pigmentUkuguqulwa kwe-Metabolism
I-Melanin anabolism ihlukaniswe ngezikhathi ezahlukene. Ososayensi bakholelwa ukuthi kungenzeka ukufunda izinto zokwenza mhlophe futhi kusebenze ngezikhathi ezahlukene ze-metabolic.
(1) Isigaba sokuqala sokwenziwa kwe-melanin
① Kuphazamisa ukuqoshwa kanye/noma i-glycosylation ye-tyrosinase; ② Kuvimbela abalawuli ekwakhekeni kwe-tyrosinase; ③ Ukulawulwa kwe-tyrosinase ngemva kokuqoshwa.
(2) Isikhathi sokwenziwa kwe-Melanin
Njenge-enzyme eyinhloko kanye ne-enzyme ekhawulela izinga lokwenziwa kwe-melanin, ama-tyrosinase inhibitors ayisiqondiso esiyinhloko socwaningo kanye nentuthuko njengamanje. Njengoba iningi lama-whitening agents afana ne-phenol kanye ne-catechol derivatives afana ngokwesakhiwo ne-tyrosine kanye ne-dopa, ama-whitening agents ahlolwe avame ukuhlukaniswa njengezithibi ezingancintisani noma ezincintisanayo ze-tyrosinase.
(3) Isigaba sokugcina sokwenziwa kwe-melanin
①Ivimbela ukudluliselwa kwe-melanosome; izinto ezinomphumela wokuvimbela i-serine protease, njenge-rwj-50353, zigwema ngokuphelele ukufakelwa kwe-epidermal okubangelwa yi-UBV; i-soybean trypsin inhibitor inomphumela ocacile wokwenza mhlophe kodwa ayinawo umphumela ebubini bamaseli e-pigment; i-Niacinamide, ingavimbela ukudluliselwa kwama-melanocyte phakathi kwama-melanocyte nama-keratinocyte; ② Ukusabalala kwe-Melanin kanye ne-metabolism, i-α-hydroxy acid, i-fatty acid yamahhala kanye ne-retinoic acid, ivuselela ukuvuselelwa kwamaseli futhi ikhuthaze ukususwa kwama-keratinocyte ane-melaninized.
Kuyaphawuleka ukuthi ucwaningo nokusetshenziswa kwezinto zokwenza mhlophe ezisekelwe ku-metabolism ye-melanin engenhla akufaneleki ukuvimbela nokwelapha ama-penis asebekhulile. Njengoba indlela yokwakheka kwe-penis esebekhulile ihlobene nokwakheka kwe-lipofuscin, izinto ezisebenzayo ezilwa nokungcola zivame ukusetshenziswa ukulibazisa nokubuyisela emuva ama-penis asebekhulile.
Isikhathi sokuthunyelwe: Julayi-29-2022
